Combinatorial effect of pH and ionic strength in the release of charged dyes from silk fibroin membranes

被引：0
|
作者：
Bertolini Neto, Jose Armando [1 ]
dos Reis, Luisa Storelli [1 ]
Tomoda, Bruno Thorihara [1 ]
de Moraes, Mariana Agostini [1 ]
机构：
[1] UNIFESP, Dept Chem Engn, Fed Univ Sao Paulo, Diadema, SP, Brazil
来源：
MRS COMMUNICATIONS | 2022年 / 12卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
ROSE-BENGAL;
D O I：
10.1557/s43579-022-00184-7
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The aim of this work was to prepare silk fibroin (SF) membranes incorporated with cationic and anionic dyes, in order to analyze the behavior of SF matrix loaded with charged compounds. For that, the combinatorial effect of pH and ionic strength on the release kinetics was assessed, showing that cationic dye has poor interaction with SF and high release rate, whereas anionic dye presented strong hydrophobic interactions with SF, being retained within the matrix. These results help elucidate the behavior of SF in the presence of charged dyes, which can be outspread for the release of charged drugs.
引用
收藏
页码：403 / 408
页数：6
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