Muscling in on mitochondrial sexual dimorphism; role of mitochondrial dimorphism in skeletal muscle health and disease

被引:7
|
作者
Nye, Gareth A. [1 ]
Sakellariou, Giorgos K. [2 ]
Degens, Hans [3 ,4 ]
Lightfoot, Adam P. [3 ]
机构
[1] Univ Manchester, Manchester Maternal & Fetal Hlth Res Ctr, Manchester M13 9WL, Lancs, England
[2] GeneFirst Ltd, Culham Sci Ctr, Abingdon OX14 3DB, Oxon, England
[3] Manchester Metropolitan Univ, Sch Healthcare Sci, Manchester M1 5GD, Lancs, England
[4] Lithuanian Sports Univ, Inst Sport Sci & Innovat, Kaunas, Lithuania
关键词
OXIDATIVE DAMAGE; EXERCISE; MASS; MECHANISMS; PROTEIN;
D O I
10.1042/CS20160940
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A recent article in Clinical Science, Ventura-Clapier et al. highlights the role of sexual dimorphism in mitochondrial function in health and disease. However, we feel the authors have overlooked arguably one of the most mitochondria-rich organs in skeletal muscle. Many studies have demonstrated that mitochondria have a central role in mediating the pathogenesis of myopathologies. However, the impact of sexual dimorphism in this context is less clear, with several studies reporting conflicting observations. For instance in ageing studies, a rodent model reported female muscles have higher antioxidant capacity compared with males; in contrast, human studies demonstrate no sex difference in mitochondrial bioenergetics and oxidative damage. These divergent observations highlight the importance of considering models and methods used to examine mitochondrial function, when interpreting these data. The use of either isolated or intact mitochondrial preparations in many studies appears likely to be a source of discord, when comparing many studies. Overall, it is now clear that more research is needed to determine if sexual dimorphism is a contributing factor in the development of myopathologies.
引用
收藏
页码:1919 / 1922
页数:4
相关论文
共 50 条
  • [21] Skeletal muscle manifestations in mitochondrial disease
    Mishra, P.
    [J]. NEUROMUSCULAR DISORDERS, 2018, 28 : S86 - S87
  • [22] Sexual dimorphism and health in prehistoric Thailand
    Clark, Angela L.
    Tayles, Nancy
    Halcrow, Sian E.
    [J]. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2013, 150 : 99 - 99
  • [23] Sexual dimorphism in the context of nutrition and health
    Pontifex, Matthew G.
    Vauzour, David
    Muller, Michael
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2024, 83 (02) : 109 - 119
  • [24] Sexual dimorphism in musculoskeletal health - Preface
    Tosi, Laura L.
    Griffin, Letha Y.
    O'Connor, Mary I.
    [J]. ORTHOPEDIC CLINICS OF NORTH AMERICA, 2006, 37 (04) : XI - XII
  • [25] Skeletal Muscle Gender Dimorphism from Proteomics
    Dimova, Kalina
    Metskas, Lauren Ann
    Kulp, Mohini
    Scordilis, Stylianos P.
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (58):
  • [26] Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions
    Valle, A.
    Guevara, R.
    Garcia-Palmer, F. J.
    Roca, P.
    Oliver, J.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 293 (04): : C1302 - C1308
  • [27] ENDOGENIC GONADAL EFFECT IN THE SEXUAL DIMORPHISM OF THE HEPATIC MITOCHONDRIAL 3-HYDROXYBUTYRATE DEHYDROGENASE
    BRIGNONE, JA
    RICCI, CR
    DEBRIGNONE, CMC
    DEMIGNONE, IR
    [J]. MEDICINA-BUENOS AIRES, 1986, 46 (05) : 531 - 531
  • [28] Sexual dimorphism in the relationship between serum leptin and skeletal health in healthy adolescents
    Maalouf, J.
    Hwalla, N.
    Mahfoud, Z.
    Obeid, O.
    El-Hajj Fuleihan, Ghada
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 : S492 - S493
  • [29] Sexual Dimorphism in Interstitial Lung Disease
    Ozaki, Mari
    Glasgow, Arlene
    Oglesby, Irene K.
    Ng, Wan Lin
    Kelly, Sile
    Greene, Catherine M.
    Durcan, Laura
    Hurley, Killian
    [J]. BIOMEDICINES, 2022, 10 (12)
  • [30] Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in the placenta with maternal obesity
    Muralimanoharan, S.
    Guo, C.
    Myatt, L.
    Maloyan, A.
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (08) : 1274 - 1281