α-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

被引：25
|
作者：
Antia, Bassey S. [1 ,2 ]
Pansanit, Acharavadee [3 ,4 ]
Ekpa, Okon D. [2 ]
Ekpe, Udofot J. [2 ]
Mahidol, Chulabhorn [1 ,3 ,4 ,5 ]
Kittakoop, Prasat [1 ,3 ,4 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Univ Calabar, Dept Pure & Appl Chem, Calabar, Nigeria
[3] Chulabhorn Grad Inst, Bangkok, Thailand
[4] Ctr Environm Hlth Toxicol & Management Chem, Chem Biol Program, Bangkok, Thailand
[5] Mahidol Univ, Chulabhorn Res Ctr, Inst Sci & Technol Res & Dev, Bangkok 10700, Thailand
来源：
PLANTA MEDICA | 2010年 / 76卷 / 03期
关键词：
Garcinia kola; Guttiferae; alpha-glucosidase inhibitor; aromatase inhibitor; antiplasmodial; biflavonoid; CANCER CHEMOPREVENTIVE AGENTS; DIABETES-MELLITUS; SEEDS; KOLAVIRON; RATS; FRACTIONS; BIFLAVANONES; MECHANISMS; FLAVONOIDS; PREVENTION;
D O I：
10.1055/s-0029-1186081
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The biflavonoid, 3 '',4',4''',5,5 '',7,7 ''-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as amajor constituent from Garcinia kola stem bark. GB1 (1) exhibited alpha-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.
引用
收藏
页码：276 / 277
页数：2
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