α-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

被引：25
|
作者：
Antia, Bassey S. [1 ,2 ]
Pansanit, Acharavadee [3 ,4 ]
Ekpa, Okon D. [2 ]
Ekpe, Udofot J. [2 ]
Mahidol, Chulabhorn [1 ,3 ,4 ,5 ]
Kittakoop, Prasat [1 ,3 ,4 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Univ Calabar, Dept Pure & Appl Chem, Calabar, Nigeria
[3] Chulabhorn Grad Inst, Bangkok, Thailand
[4] Ctr Environm Hlth Toxicol & Management Chem, Chem Biol Program, Bangkok, Thailand
[5] Mahidol Univ, Chulabhorn Res Ctr, Inst Sci & Technol Res & Dev, Bangkok 10700, Thailand
来源：
PLANTA MEDICA | 2010年 / 76卷 / 03期
关键词：
Garcinia kola; Guttiferae; alpha-glucosidase inhibitor; aromatase inhibitor; antiplasmodial; biflavonoid; CANCER CHEMOPREVENTIVE AGENTS; DIABETES-MELLITUS; SEEDS; KOLAVIRON; RATS; FRACTIONS; BIFLAVANONES; MECHANISMS; FLAVONOIDS; PREVENTION;
D O I：
10.1055/s-0029-1186081
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The biflavonoid, 3 '',4',4''',5,5 '',7,7 ''-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as amajor constituent from Garcinia kola stem bark. GB1 (1) exhibited alpha-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.
引用
收藏
页码：276 / 277
页数：2
相关论文
共 50 条
  • [1] Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola
    Han, QB
    Lee, SF
    Qiao, CF
    He, ZD
    Song, JZ
    Sun, HD
    Xu, HX
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (08) : 1034 - 1036
  • [2] Analgesic anti-inflammatory anti-pyretic activities of Garcinia hydroxybiflavanonol (GB1) from Garcinia kola
    Chinaka O. Nwaehujor
    Rita I. Udegbunam
    Julius O. Ode
    Sunday O. Udegbunam
    Journal of the Korean Society for Applied Biological Chemistry, 2015, 58 : 91 - 96
  • [3] Analgesic anti-inflammatory anti-pyretic activities of Garcinia hydroxybiflavanonol (GB1) from Garcinia kola
    Nwaehujor, Chinaka O.
    Udegbunam, Rita I.
    Ode, Julius O.
    Udegbunam, Sunday O.
    JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2015, 58 (01): : 91 - 96
  • [4] Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii
    Minami, T
    Iwamoto, M
    Ohtsu, H
    Ohishi, H
    Tanaka, R
    Yoshitake, A
    PLANTA MEDICA, 2002, 68 (08) : 742 - 745
  • [5] α-Glucosidase inhibitory constituents from stem bark of Terminalia superba (Combretaceae)
    Wansi, Jean Duplex
    Lallemand, Marie-Christine
    Chiozem, David Daco
    Toze, Flavien Aristide A.
    Mbaze, Luc Meva'a
    Naharkhan, Shamsun
    Iqbal, Muhammad Choudhary
    Tillequin, Francois
    Wandji, Jean
    Fomum, Zacharias Tanee
    PHYTOCHEMISTRY, 2007, 68 (15) : 2096 - 2100
  • [6] A new flavonoid from the leaves of Garcinia mckeaniana Craib and α-glucosidase and acetylcholinesterase inhibitory activities
    Nguyen, Thi Thu Ha
    Nguyen, Van Tuyen
    Van Cuong, Pham
    Nguyen Thanh, Tra
    Le Thi, Tu Anh
    Mai Huong, Doan Thi
    Truong, Bich Ngan
    Litaudon, Marc
    Ninh The, Son
    NATURAL PRODUCT RESEARCH, 2022, 36 (19) : 5074 - 5080
  • [7] α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana
    Phu Hoang Dang
    Hai Xuan Nguyen
    Truc Thanh Thi Duong
    Thao Kim Thi Tran
    Phuc Thi Nguyen
    Trang Kieu Thi Vu
    Hung Chi Vuong
    Nguyen Huu Trong Phan
    Mai Thanh Thi Nguyen
    Nhan Trung Nguyen
    Awale, Suresh
    JOURNAL OF NATURAL PRODUCTS, 2017, 80 (04): : 1087 - 1095
  • [8] α-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae)
    Mbaze, Luc Meva'a
    Poumale, Herve Martial P.
    Wansi, Jean Duplex
    Lado, Jean Alexandre
    Khan, Shamsun Nahar
    Iqbal, Muhammad Choudhary
    Ngadjui, Bonaventure Tchaleu
    Laatsch, Hartmut
    PHYTOCHEMISTRY, 2007, 68 (05) : 591 - 595
  • [9] α-glucosidase Inhibitory and Antioxidant Activities of Entada spiralis Ridl. (Sintok) Stem Bark Extracts
    Opeyemi, Roheem Fatimah
    Zaiton, Mat So'ad Siti
    Uddin, Ahmed Qamar
    Norazian, Mohd Hassan
    PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE, 2019, 42 (01): : 139 - 153
  • [10] α-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis
    Kouam, SF
    Khan, SN
    Krohn, K
    Ngadjui, BT
    Kapche, DGWF
    Yapna, DB
    Zareem, S
    Moustafa, AMY
    Choudhary, MI
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (02): : 229 - 233
12345