The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

被引：4
|
作者：
Kumari, Poonam [1 ]
Tarighi, Shahriar [1 ]
Braun, Thomas [1 ]
Ianni, Alessandro [1 ]
机构：
[1] Max Planck Inst Heart & Lung Res, Dept Cardiac Dev & Remodeling, Bad Nauheim, Germany
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 03期
关键词：
SIRT7; nucleophosmin; p53; nucleolus; ultraviolet irradiation;
D O I：
10.1080/23723556.2021.1896349
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.
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页数：3
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