Chemisorption Mechanism of DNA on Mg/Fe Layered Double Hydroxide Nanoparticles: Insights into Engineering Effective SiRNA Delivery Systems

被引：24

作者：

Lu, Mingshen ^{[1
]}

Shan, Zhi ^{[2
]}

Andrea, Kori ^{[2
]}

MacDonald, Bruce ^{[2
]}

Beale, Stefanie ^{[4
]}

Curry, Dennis E. ^{[2
,5
]}

Wang, Li ^{[6
]}

Wang, Shujun

Oakes, Ken D. ^{[2
,3
]}

Bennett, Craig ^{[4
]}

Wu, Wenhui ^{[1
]}

Zhang, Xu ^{[2
]}

机构：

[1] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China

[2] Cape Breton Univ, Verschuren Ctr Sustainabil Energy & Environm, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[3] Cape Breton Univ, Dept Biol, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada

[4] Acadia Univ, Dept Phys, Wolfville, NS B4P 2R6, Canada

[5] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada

[6] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310018, Zhejiang, Peoples R China

来源：

LANGMUIR | 2016年 / 32卷 / 11期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

DRUG-DELIVERY; GOLD NANOPARTICLES; SURFACE SCIENCE; CELLULAR UPTAKE; ADSORPTION; RELEASE; GRAPHENE; OLIGONUCLEOTIDES; INTERCALATION; NANOHYBRIDS;

D O I：

10.1021/acs.langmuir.5b04643

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Layered double hydroxide nanoparticles (LDH NPs) have attracted interest as an effective gene delivery vehicle in biomedicine. Recent advances in clinic trials have demonstrated the efficacy of Mg/Fe LDHs for hyperphosphatemia treatment, but their feasibility for gene delivery has not been systematically evaluated. As a starting point, we aimed to study the interaction between oligo-DNA and Mg/Fe LDH NPs. Our investigation revealed the chemisorption mechanism of DNA on Mg/Fe LDH surfaces, wherein the phosphate backbone of the DNA polymer coordinates with the metal cations of the LDH lattice via the ligand-exchange process. This mechanistic insight may facilitate future gene delivery applications using Mg/Fe LDH NPs.

引用

页码：2659 / 2667

页数：9

共 31 条

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