Chemisorption Mechanism of DNA on Mg/Fe Layered Double Hydroxide Nanoparticles: Insights into Engineering Effective SiRNA Delivery Systems

被引：24
|
作者：
Lu, Mingshen [1 ]
Shan, Zhi [2 ]
Andrea, Kori [2 ]
MacDonald, Bruce [2 ]
Beale, Stefanie [4 ]
Curry, Dennis E. [2 ,5 ]
Wang, Li [6 ]
Wang, Shujun
Oakes, Ken D. [2 ,3 ]
Bennett, Craig [4 ]
Wu, Wenhui [1 ]
Zhang, Xu [2 ]
机构：
[1] Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
[2] Cape Breton Univ, Verschuren Ctr Sustainabil Energy & Environm, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
[3] Cape Breton Univ, Dept Biol, 1250 Grand Lake Rd, Sydney, NS B1P 6L2, Canada
[4] Acadia Univ, Dept Phys, Wolfville, NS B4P 2R6, Canada
[5] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada
[6] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310018, Zhejiang, Peoples R China
来源：
LANGMUIR | 2016年 / 32卷 / 11期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
DRUG-DELIVERY; GOLD NANOPARTICLES; SURFACE SCIENCE; CELLULAR UPTAKE; ADSORPTION; RELEASE; GRAPHENE; OLIGONUCLEOTIDES; INTERCALATION; NANOHYBRIDS;
D O I：
10.1021/acs.langmuir.5b04643
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Layered double hydroxide nanoparticles (LDH NPs) have attracted interest as an effective gene delivery vehicle in biomedicine. Recent advances in clinic trials have demonstrated the efficacy of Mg/Fe LDHs for hyperphosphatemia treatment, but their feasibility for gene delivery has not been systematically evaluated. As a starting point, we aimed to study the interaction between oligo-DNA and Mg/Fe LDH NPs. Our investigation revealed the chemisorption mechanism of DNA on Mg/Fe LDH surfaces, wherein the phosphate backbone of the DNA polymer coordinates with the metal cations of the LDH lattice via the ligand-exchange process. This mechanistic insight may facilitate future gene delivery applications using Mg/Fe LDH NPs.
引用
收藏
页码：2659 / 2667
页数：9
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