Three new coumarin glycosides from the stems of Hydrangea paniculata

被引：8
|
作者：
Ma, Jie
Li, Chuang-Jun
Yang, Jing-Zhi
Li, Yan
Bao, Xiu-Qi
Chen, Nai-Hong
Zhang, Dong-Ming [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Hydrangea paniculata; coumarin glycosides; neuroprotective; hepatoprotective; anti-inflammatory; ROOT; SAPONINS;
D O I：
10.1080/10286020.2017.1305958
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.
引用
收藏
页码：320 / 326
页数：7
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