One-pot synthesis of primary tert-alkylamines by the addition of organometallic reagents to nitriles mediated by Ti(Oi-Pr)4

被引：16
|
作者：
Tomashenko, Olesya
Sokolov, Viktor
Tomashevskiy, Alexander
de Meijere, Armin
机构：
[1] St Petersburg State Univ, Dept Chem, St Petersburg 198504, Russia
[2] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
SYNLETT | 2007年 / 04期
关键词：
amines; nitriles; nucleophilic addition; organometallic reagents; titanium tetraisopropoxide;
D O I：
10.1055/s-2007-967980
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A number of primary tert-alkylamines (18 examples, 25-72% yields) have been prepared according to a simple one-pot procedure by the addition of organometallic reagents such as Grignard reagents and organolithium compounds to nitriles in the presence of Ti(Oi-Pr)(4).
引用
收藏
页码：652 / 654
页数：3
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