The number of androgen receptor CAG repeats and mortality in men

被引:4
|
作者
Heald, Adrian [1 ,2 ,3 ]
Cook, Michael [4 ]
Antonio, Leen [5 ,6 ]
Vanderschueren, Dirk [5 ,6 ]
Javed, Ahmed [2 ,3 ]
Fachim, Helene [2 ,3 ,4 ]
Hackett, Geoff [7 ]
Wu, Fred [4 ,8 ]
O'Neill, Terence [4 ,9 ]
机构
[1] Salford Royal Hosp, Dept Endocrinol & Diabet, Salford, Lancs, England
[2] Univ Manchester, Sch Med, Manchester, Lancs, England
[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
[4] Univ Manchester, Ctr Epidemiol Versus Arthrit, Manchester, Lancs, England
[5] Univ Hosp Leuven, Dept Endocrinol, Leuven, Belgium
[6] Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Leuven, Belgium
[7] Aston Univ, Med Sch, Birmingham, W Midlands, England
[8] Univ Manchester, Manchester Royal Infirm, Dept Endocrinol, Manchester, Lancs, England
[9] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England
来源
AGING MALE | 2022年 / 25卷 / 01期
关键词
EMAS; CAG; testosterone; male; mortality; LATE-ONSET HYPOGONADISM; SERUM TESTOSTERONE; RISK-FACTOR; POLYMORPHISM; LEPTIN; MASS;
D O I
10.1080/13685538.2022.2061452
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction The androgen receptor (AR) mediates peripheral effects of testosterone. Evidence suggests that the number of CAG repeats in exon-1 of the AR gene negatively correlates with AR transcriptional activity. The aim of this analysis was to determine the association between CAG repeat number and mortality in men. Methods Men aged 40-79 years were recruited from primary care for participation in the UK arm of the European Male Aging Study between 2003 and 2005. Cox proportional hazards modelling was used to determine the association between CAG repeat number/mortality. Results were expressed as hazard ratios(HR)/95% confidence intervals (CI). Results 312 men were followed up. The mean baseline age was 59.5 years. At follow up, 85/312(27%) men had died. CAG repeat length ranged from 14 to 39, with the highest proportion of CAG repeat number at 21 repeats(16.4%). In a multivariable model, using men with CAG repeat numbers of 22-23 as the reference, men with a lower number of CAG repeats(<22) showed a trend for a higher mortality in the follow-up period (HR 1.46 (0.75, 2.81)) as did men with higher number of repeats (>23) (1.37 (0.65, 2.91)). Conclusion Our data suggest that CAG repeat number may partially influence the risk of mortality in men. Further larger studies are required to quantify the effect.
引用
收藏
页码:167 / 172
页数:6
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