Mechanism of CINC-1 production from gastric epithelial cells stimulated with TNF-α

被引：0

作者：

Handa, O ^{[1
]}

Naito, Y ^{[1
]}

Takagi, T ^{[1
]}

Ueda, M ^{[1
]}

Ishikawa, T ^{[1
]}

Imamoto, E ^{[1
]}

Tomatsuri, N ^{[1
]}

Uchiyama, K ^{[1
]}

Shimozawa, M ^{[1
]}

Katada, K ^{[1
]}

Ueda, T ^{[1
]}

Kokura, S ^{[1
]}

Ichikawa, H ^{[1
]}

Yoshida, N ^{[1
]}

Yoshikawa, T ^{[1
]}

Gediminas, C ^{[1
]}

Kvietys, PR ^{[1
]}

机构：

[1] Lawson Hlth Res Inst, Vasc Cell Biol Inflammat Program, London, ON, Canada

来源：

XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2002年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CINC-1 has been suggested to play a role as a mediator of inflammatory reactions with neutrophil infiltration in rats. In this study, e investigate the mechanism of CINC-1 production from rat gastric mucosal cell (RGM-1) in response to TNF-alpha stimulation in vitro. TNF-alpha stimulation results in, 1) up-regulation of CINC-1 mRNA and protein, 2) NF-kappaB p65 activation, and 3) increase in cH(2)DCF-DA oxidation. These changes were reversed by several inhibitors against NF-kappaB activation, endogenous reactive oxygen production. In conclusion, TNF-alpha-induced CINC-1 production from RGM-1 cells depends on NF-kappaB and oxidative stress.

引用

页码：347 / 350

页数：4

共 50 条

[21] Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-α-stimulated human colonic epithelial HT-29 cells
Yomogida, Shin
Hua, Jian
Sakamoto, Koji
Nagaoka, Isao
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2008, 22 (02) : 205 - 211
[22] Up-regulation of TFF1 (pS2) expression by TNF-α in gastric epithelial cells
Koike, Takero
Shimada, Tadahito
Fujii, Yoichiro
Chen, Guozhong
Tabei, Kyoko
Namatame, Takashi
Yamagata, Michiko
Tajima, Akihiro
Yoneda, Masashi
Terano, Akira
Hiraishi, Hideyuki
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (06) : 936 - 942
[23] Neutrophil migration induced by IL-8-activated mast cells is mediated by CINC-1
Ramos, CDL
Heluy-Neto, NE
Ribeiro, RA
Ferreira, SH
Cunha, FQ
CYTOKINE, 2003, 21 (05) : 214 - 223
[24] The cytokines TNF, MCP-1 and CINC-1 mediate diminished dilation of middle cerebral artery after ischemic stroke in rats
Broskova, Zuzana
Anthony, Daniel
Bagi, Zsolt
FASEB JOURNAL, 2014, 28 (01):
[25] Elasticity changes anti-correlate with NO production for human endothelial cells stimulated with TNF-α
Agnieszka M. Szczygiel
Grzegorz Brzezinka
Marta Targosz-Korecka
Stefan Chlopicki
Marek Szymonski
Pflügers Archiv - European Journal of Physiology, 2012, 463 : 487 - 496
[26] Elasticity changes anti-correlate with NO production for human endothelial cells stimulated with TNF-α
Szczygiel, Agnieszka M.
Brzezinka, Grzegorz
Targosz-Korecka, Marta
Chlopicki, Stefan
Szymonski, Marek
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2012, 463 (03): : 487 - 496
[27] Mechanism of ATP-stimulated TNF-α production through activation of MAP kinase in rat microglia
Ido, K
Suzuki, T
Inoue, A
Kohsaka, S
Inoue, K
Hide, I
Nakata, Y
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88 : 90P - 90P
[28] IL-1β Augments TNF-α-Mediated Inflammatory Responses from Lung Epithelial Cells
Saperstein, Sara
Chen, Linlin
Oakes, David
Pryhuber, Gloria
Finkelstein, Jacob
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2009, 29 (05): : 273 - 284
[29] Influence of age on the production of interleukin-8-like chemokine (GRO/CINC-1) in rat nasal mucosa
T. Himi
I. Yoshioka
A. Kataura
European Archives of Oto-Rhino-Laryngology, 1997, 254 : 101 - 104
[30] Contribution of TNFα, IL-1β and CINC-1 for articular incapacitation, edema and cell migration in a model of LPS-induced reactive arthritis
Bressan, Elisangela
Cunha, Fernando De Queiroz
Tonussi, Carlos Rogerio
CYTOKINE, 2006, 36 (1-2) : 83 - 89

← 1 2 3 4 5 →