Mechanism of CINC-1 production from gastric epithelial cells stimulated with TNF-α

被引：0

作者：

Handa, O ^{[1
]}

Naito, Y ^{[1
]}

Takagi, T ^{[1
]}

Ueda, M ^{[1
]}

Ishikawa, T ^{[1
]}

Imamoto, E ^{[1
]}

Tomatsuri, N ^{[1
]}

Uchiyama, K ^{[1
]}

Shimozawa, M ^{[1
]}

Katada, K ^{[1
]}

Ueda, T ^{[1
]}

Kokura, S ^{[1
]}

Ichikawa, H ^{[1
]}

Yoshida, N ^{[1
]}

Yoshikawa, T ^{[1
]}

Gediminas, C ^{[1
]}

Kvietys, PR ^{[1
]}

机构：

[1] Lawson Hlth Res Inst, Vasc Cell Biol Inflammat Program, London, ON, Canada

来源：

XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2002年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CINC-1 has been suggested to play a role as a mediator of inflammatory reactions with neutrophil infiltration in rats. In this study, e investigate the mechanism of CINC-1 production from rat gastric mucosal cell (RGM-1) in response to TNF-alpha stimulation in vitro. TNF-alpha stimulation results in, 1) up-regulation of CINC-1 mRNA and protein, 2) NF-kappaB p65 activation, and 3) increase in cH(2)DCF-DA oxidation. These changes were reversed by several inhibitors against NF-kappaB activation, endogenous reactive oxygen production. In conclusion, TNF-alpha-induced CINC-1 production from RGM-1 cells depends on NF-kappaB and oxidative stress.

引用

页码：347 / 350

页数：4

共 50 条

[1] Mechanism of cinc-1 production from gastric epithelial cells stimulated with TNF-alpha
Handa, O
Naito, Y
Takagi, T
Ueda, M
Ishikawa, T
Imamoto, E
Tomatsuri, N
Uchiyama, K
Shimozawa, M
Ueda, T
Katada, K
Sakamoto, N
Kokura, S
Ichikawa, H
Yoshida, N
Yoshikawa, T
Gediminas, C
Kvietys, PR
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 : S132 - S132
[2] Rat CXC chemokine GRO/CINC-1 paradoxically stimulates the growth of gastric epithelial cells
Suzuki, H
Mori, M
Seto, K
Shibata, F
Nagahashi, S
Kawaguchi, C
Suzuki, M
Matsui, H
Watanabe, K
Miura, S
Ishii, H
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2000, 14 : 94 - 100
[3] Fatty acids enhance GRO/CINC-1 and interleukin-6 production in rat intestinal epithelial cells
Yoshida, H
Miura, S
Kishikawa, H
Hirokawa, M
Nakamizo, H
Nakatsumi, RC
Suzuki, H
Saito, H
Ishii, H
JOURNAL OF NUTRITION, 2001, 131 (11): : 2943 - 2950
[4] Reynosin from Sassurea lappa as inhibitor on CINC-1 induction in LPS-stimulated NRK-52E cells
Jung, JH
Ha, JY
Min, KR
Shibata, F
Nakagawa, H
Kang, SS
Chang, IM
Kim, YS
PLANTA MEDICA, 1998, 64 (05) : 454 - 455
[5] Rat GRO/CINC-1, a member of CXC chemokine, has a growth-stimulating activity for rat gastric epithelial cells.
Suzuki, H
Mori, M
Seto, K
Shibata, F
Suzuki, M
Miura, S
Watanabe, K
Ishii, H
GASTROENTEROLOGY, 1998, 114 (04) : A299 - A299
[6] Production of MCP-1 and CINC-1 in rat brain and cultured astrocytes was stimulated by endothelin ETB receptor agonist
Koyama, Yutaka
Baba, Akemichi
Matsuda, Toshio
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 78P - 78P
[7] TNF-α, IL-1β, IL-6, and cinc-1 levels in rat brain after meningitis induced by Streptococcus pneumoniae
Barichello, Tatiana
dos Santos, Ivonete
Savi, Geovana D.
Simoes, Lutiana R.
Silvestre, Tiago
Comim, Clarissa M.
Sachs, Daniela
Teixeira, Mauro M.
Teixeira, Antonio L.
Quevedo, Joao
JOURNAL OF NEUROIMMUNOLOGY, 2010, 221 (1-2) : 42 - 45
[8] Production of hemopexin by TNF-α stimulated human mesangial cells
Kapojos, JJ
van den Berg, A
van Goor, H
Poelstra, WMTLK
Poelstra, K
Borghuis, T
Bakker, WW
KIDNEY INTERNATIONAL, 2003, 63 (05) : 1681 - 1686
[9] IL-27 Modulates Chemokine Production in TNF-α-Stimulated Human Oral Epithelial Cells
Hosokawa, Yoshitaka
Hosokawa, Ikuko
Ozaki, Kazumi
Matsuo, Takashi
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (03) : 1198 - 1206
[10] Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition
Rocha, Lilian Wunsch
Magayewski Bonet, Ivan Jose
Tambeli, Claudia Herrera
de-Faria, Felipe Meira
Parada, Carlos Amilcar
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 830 : 87 - 94

← 1 2 3 4 5 →