Working memory impairment in multiple sclerosis relapsing-remitting patients with episodic memory deficits

被引:16
|
作者
Fuso, Simone Freitas [1 ]
Callegaro, Dagoberto [2 ]
Pompeia, Sabine [1 ]
Bueno, Orlando F. A. [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
[2] Univ Sao Paulo, Ctr Myelin Disorders, Clin Hosp, Dept Neurol, Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
memory; multiple sclerosis; memory short-term; neuropsychological tests; cognition; SPEED; DISTURBANCE; EFFICIENCY; CAPACITY; MS;
D O I
10.1590/S0004-282X2010000200010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Episodic memory is impaired in multiple sclerosis (MS) patients, possibly because of deficits in working memory (WM) functioning. If so, WM alterations should necessarily be found in patients with episodic memory deficits, but this has not yet been demonstrated. In this study we aimed at determining whether episodic memory deficits in relapsing-remitting MS are found in conjunction with impaired WM. We evaluated 32 MS patients and 32 matched healthy controls. Nineteen of the 32 patients had episodic memory impairment, and as a group only these individuals showed deficits in WM capacity, which may lead to difficulty in encoding, and/or retrieving information from episodic memory.
引用
收藏
页码:205 / 211
页数:7
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