Synthesis, characterization, and antitumour studies of metal chelates of some synthetic curcuminoids

被引：61
|
作者：
Krishnankutty, K [1 ]
John, VD [1 ]
机构：
[1] Univ Calicut, Dept Chem, Calicut 673635, Kerala, India
来源：
SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY | 2003年 / 33卷 / 02期
关键词：
curcuminoids; 1,7-diarylheptanoids; metal chelates; antitumour activity; NMR spectra; mass spectra;
D O I：
10.1081/SIM-120017791
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Four new curcuminoid (1,7-diaryl-1,6-heptadiene-3,5-diones) analogues and their vanadyl(IV), cobalt(II), nickel(II) and copper(II) chelates of ML2 stoichiometry have been synthesized and characterized by electronic, IR, H-1 NMR, ESR and mass spectral data. The in vitro and in vivo antitumour activity of these 1,7-diarylheptanoids and their copper(II) chelates showed that chelation remarkably enhanced cytotoxic activity and other antitumour properties.
引用
收藏
页码：343 / 358
页数：16
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