Synthesis, characterization, and antitumour studies of metal chelates of some synthetic curcuminoids

被引：61

作者：

Krishnankutty, K ^{[1
]}

John, VD ^{[1
]}

机构：

[1] Univ Calicut, Dept Chem, Calicut 673635, Kerala, India

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY | 2003年 / 33卷 / 02期

关键词：

curcuminoids; 1,7-diarylheptanoids; metal chelates; antitumour activity; NMR spectra; mass spectra;

D O I：

10.1081/SIM-120017791

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Four new curcuminoid (1,7-diaryl-1,6-heptadiene-3,5-diones) analogues and their vanadyl(IV), cobalt(II), nickel(II) and copper(II) chelates of ML2 stoichiometry have been synthesized and characterized by electronic, IR, H-1 NMR, ESR and mass spectral data. The in vitro and in vivo antitumour activity of these 1,7-diarylheptanoids and their copper(II) chelates showed that chelation remarkably enhanced cytotoxic activity and other antitumour properties.

引用

页码：343 / 358

页数：16

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