Efficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel-Crafts Reactions of Donor-Acceptor Aziridines with N,N-Dialkylanilines

被引：5

作者：

Kim, Yerin ^{[1
]}

Kwon, Yong Il ^{[1
]}

Kim, Sung-Gon ^{[1
]}

机构：

[1] Kyonggi Univ, Dept Chem, 154-42 Gwanggyosan Ro, Suwon 16227, South Korea

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

diarylmethylamine; Friedel-Crafts reaction; donor-acceptor aziridine; N; N-dialkylaniline; Lewis acid; ASYMMETRIC 3+2 CYCLOADDITION; CHIRAL DIENE LIGANDS; H BOND ARYLATION; N-TOSYLAZIRIDINES; C-ARYLATION; N; N-DIALKYL-3-VINYLANILINES; DERIVATIVES; FUNCTIONALIZATION; TOSYLARYLIMINES; ALDEHYDES;

D O I：

10.1055/s-0039-1690731

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for efficient and mild synthesis of diarylmethylamine scaffold, via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N,N-dialkylanilines to afford a biologically important diarylmethylamine derivatives in high yields (up to 88%), is presented. This reaction is suitable for the synthesis of various diarylmethylamine derivatives and has a broad scope for electron-rich arenes, including dimethoxybenzene.

引用

页码：281 / 289

页数：9

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