Management of Nonfunctioning Recurrent Pituitary Adenomas

被引：9

作者：

Farrell, Christopher J. ^{[1
]}

Garzon-Muvdi, Tomas ^{[1
]}

Fastenberg, Judd H. ^{[2
]}

Nyquist, Gurston G. ^{[2
]}

Rabinowitz, Mindy R. ^{[2
]}

Rosen, Marc R. ^{[2
]}

Evans, James J. ^{[1
]}

机构：

[1] Thomas Jefferson Univ Hosp, Dept Neurol Surg, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ Hosp, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2019年 / 30卷 / 04期

关键词：

Recurrent pituitary tumor; KNOSP grade; Transsphenoidal surgery; Pituitary adenomas; ENDOSCOPIC ENDONASAL APPROACH; REPEAT TRANSSPHENOIDAL SURGERY; GAMMA-KNIFE RADIOSURGERY; STEREOTACTIC RADIOSURGERY; CUSHING-DISEASE; RADIOTHERAPY; SELLAR; TUMORS; RECONSTRUCTION; OUTCOMES;

D O I：

10.1016/j.nec.2019.05.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pituitary adenomas are typically slow-growing benign tumors. However, 50% to 60% of tumors progress following subtotal resection and up to 30% recur after apparent complete resection. Options for treatment of recurrent pituitary adenomas include repeat surgical resection, radiation therapy, and systemic therapies. There is no consensus approach for the management of recurrent pituitary adenomas. This article reviews the natural history of recurrent adenomas and emerging biomarkers predictive of clinical behavior as well as the outcomes associated with the various treatment modalities for these challenging tumors, with an emphasis on the surgical treatment.

引用

页码：473 / +

页数：11

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