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Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Ocular Dis, Guangdong Prov Key Lab Ophthalmol & Visual Sci, State Key Lab Ophthalmol,Zhongshan Ophthalm Ctr, Guangzhou, Peoples R China Sun Yat Sen Univ, Guangdong Prov Clin Res Ctr Ocular Dis, Guangdong Prov Key Lab Ophthalmol & Visual Sci, State Key Lab Ophthalmol,Zhongshan Ophthalm Ctr, Guangzhou, Peoples R China