Closed loop control of perfusion systems in high-density cell culture

被引：0
|
作者：
Bock, A. [1 ]
Reichl, U. [1 ,2 ]
机构：
[1] Max Planck Inst Dynam Complex Tech Syst Magdeburg, Sandtorstr 1, D-39106 Magdeburg, Germany
[2] Otto von Guericke Univ, D-39106 Magdeburg, Germany
来源：
CELL TECHNOLOGY FOR CELL PRODUCTS | 2007年
关键词：
bioprocess; vaccine; influenza; virus; microcarrier; mammalian cell culture; Madin-Darby canine kidney; cell growth; perfusion; closed loop; open loop; dilution rate; enzyme sensor; on-line monitoring; YSI; 2700; bioreactor;
D O I：
10.1007/978-1-4020-5476-1_94
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The use of a perfusion system prevented unspecific inhibitions effects on cell growth for batch cultivations of adherent MDCK cells used for an equine influenza A vaccine production process. It also increased viable cell numbers. An enzyme sensor for monitoring and closed loop control of metabolites operated stable for at least 55 hours.
引用
收藏
页码：549 / +
页数：2
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