Closed loop control of perfusion systems in high-density cell culture

被引：0
|
作者：
Bock, A. [1 ]
Reichl, U. [1 ,2 ]
机构：
[1] Max Planck Inst Dynam Complex Tech Syst Magdeburg, Sandtorstr 1, D-39106 Magdeburg, Germany
[2] Otto von Guericke Univ, D-39106 Magdeburg, Germany
来源：
CELL TECHNOLOGY FOR CELL PRODUCTS | 2007年
关键词：
bioprocess; vaccine; influenza; virus; microcarrier; mammalian cell culture; Madin-Darby canine kidney; cell growth; perfusion; closed loop; open loop; dilution rate; enzyme sensor; on-line monitoring; YSI; 2700; bioreactor;
D O I：
10.1007/978-1-4020-5476-1_94
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The use of a perfusion system prevented unspecific inhibitions effects on cell growth for batch cultivations of adherent MDCK cells used for an equine influenza A vaccine production process. It also increased viable cell numbers. An enzyme sensor for monitoring and closed loop control of metabolites operated stable for at least 55 hours.
引用
收藏
页码：549 / +
页数：2
相关论文
共 50 条
  • [21] Development of rolled scaffold for high-density adherent cell culture
    YekrangSafakar, Ashkan
    Hamel, Katie M.
    Mehrnezhad, Ali
    Jung, Jangwook P.
    Park, Kidong
    [J]. BIOMEDICAL MICRODEVICES, 2020, 22 (01)
  • [22] Development of rolled scaffold for high-density adherent cell culture
    Ashkan YekrangSafakar
    Katie M. Hamel
    Ali Mehrnezhad
    Jangwook P. Jung
    Kidong Park
    [J]. Biomedical Microdevices, 2020, 22
  • [23] HIGH-DENSITY CULTURE OF MOUSE-HUMAN HYBRIDOMA CELLS USING A NEW PERFUSION CULTURE VESSEL
    TOKASHIKI, M
    HAMAMOTO, K
    TAKAZAWA, Y
    ICHIKAWA, Y
    [J]. KAGAKU KOGAKU RONBUNSHU, 1988, 14 (03) : 337 - 341
  • [24] Long-term closed-loop recycling of high-density polyethylene/flax composites
    Benoit, Nathalie
    Gonzalez-Nunez, Ruben
    Rodrigue, Denis
    [J]. PROGRESS IN RUBBER PLASTICS AND RECYCLING TECHNOLOGY, 2018, 34 (04) : 171 - 199
  • [25] High-density rearing of red-bellied pacu in two closed systems
    Poleo, German
    Vicente Aranbarrio, Jose
    Mendoza, Lismen
    Romero, Oneida
    [J]. PESQUISA AGROPECUARIA BRASILEIRA, 2011, 46 (04) : 429 - 437
  • [26] Fermenter temperature as a pool for control of high-density perfusion cultures of mammalian cells
    Chuppa, S
    Tsai, YS
    Yoon, S
    Shackleford, S
    Rozales, C
    Bhat, R
    Tsay, G
    Matanguihan, C
    Konstantinov, K
    Naveh, D
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 1997, 55 (02) : 328 - 338
  • [27] A method for the design of 3D scaffolds for high-density cell attachment and determination of optimum perfusion culture conditions
    Provin, Christophe
    Takano, Kiyoshi
    Sakai, Yasuyuki
    Fujii, Teruo
    Shirakashi, Ryo
    [J]. JOURNAL OF BIOMECHANICS, 2008, 41 (07) : 1436 - 1449
  • [28] HIGH-DENSITY CELL-CULTURE BY MEMBRANE-BASED CELL RECYCLE
    CHANG, HN
    YOO, IK
    KIM, BS
    [J]. BIOTECHNOLOGY ADVANCES, 1994, 12 (03) : 467 - 487
  • [29] Solution to the high dissolved CO2 problem in high-density perfusion culture of mammalian cells
    Matanguihan, R
    Sajan, E
    Zachariou, M
    Olson, C
    Michaels, J
    Thrift, J
    Konstantinov, K
    [J]. ANIMAL CELL TECHNOLOGY: FROM TARGET TO MARKET, 2001, 1 : 399 - 402
  • [30] From chemostats to high-density perfusion: the progression of continuous mammalian cell cultivation
    Wong, H. Edward
    Chen, Chun
    Le, Huong
    Goudar, Chetan T.
    [J]. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2022, 97 (09) : 2297 - 2304
12345