Protective effects of tempol in an experimental ovarian ischemia-reperfusion injury model in female Wistar albino rats

被引：16
|
作者：
Pinar, Neslihan [1 ]
Karapinar, Oya Soylu [2 ]
Ozcan, Oguzhan [3 ]
Dogan, Esin Atik [4 ]
Bayraktar, Suphi [5 ]
机构：
[1] Mustafa Kemal Univ, Sch Med, Dept Med Pharmacol, Antakya, Turkey
[2] Mustafa Kemal Univ, Sch Med, Dept Obstet & Gynaecol, Antakya, Turkey
[3] Mustafa Kemal Univ, Sch Med, Dept Biochem, Antakya, Turkey
[4] Mustafa Kemal Univ, Sch Med, Dept Pathol, Antakya, Turkey
[5] Cukurova Univ, Sch Med, Dept Med Microbiol, Adana, Turkey
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2017年 / 95卷 / 07期
关键词：
ovarian ischemia-reperfusion; tempol; oxidative stress; PERMEABLE RADICAL SCAVENGER; LIPOIC ACID; ISCHEMIA/REPERFUSION;
D O I：
10.1139/cjpp-2016-0309
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to investigate the antioxidant effects of tempol on ovarian ischemia-reperfusion (I/R) injury in rats. Forty female Wistar albino rats were randomly divided into 5 groups: Group I, sham; Group II, ischemia (I); Group III, I/R; Group IV, I/R + tempol 30 mg/kg i.p; Group V, I/R + tempol 50 mg/kg i.p. Oxidative stress index (OSI) was significantly higher in the ischemia group and the I/R group than in the sham group. Catalase levels were significantly lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. Glutathione peroxidase levels were lower in the I/R group than in the I/R + tempol 30 mg/kg i.p. and the I/R + tempol 50 mg/kg i.p. groups. MDA levels were significantly lower in the I/R + tempol 30 mg/kg i.p. group and the I/R + tempol 50 mg/kg i.p. group than in the I/R group. The levels of the histopathological parameters were significantly decreased in the I/R + tempol 50 mg/kg i.p. group compared with the I/R group. Tempol can be used for reducing ovarian I/R injury.
引用
收藏
页码：861 / 865
页数：5
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