Characterization of telomerase-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell cultures

被引：0
|
作者：
Gu, Y. [1 ]
Li, H. [1 ]
Miki, J. [1 ]
Kim, K. H. [1 ]
Furusato, B. [1 ]
Sesterhenn, I. A. [2 ,3 ]
Mcleod, D. G. [1 ]
Ewing, C. M. [4 ]
Srivastava, S. [1 ]
Isaacs, W. B. [4 ]
Rhim, J. S. [1 ]
机构：
[1] USUHS, Ctr Prostate Dis Res, Bethesda, MD 20814 USA
[2] Armed Forces Inst Pathol, Washington, DC 20306 USA
[3] Walter Reed Army Med Ctr, Washington, DC 20307 USA
[4] Johns Hopkins Med Inst, Baltimore, MD 21205 USA
来源：
UICC WORLD CANCER CONGRESS, PROCEEDINGS | 2006年
关键词：
D O I：
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently generated five immortal human prostate epithelial cell cultures derived from both the benign and malignant tissues of prostate cancer patients with telomerase, a gene that prevents cellular senescence. Examination of these cell lines for their morphologies and proliferative capacities, to respond to androgen stimulation, to grow above the agar layer, to form tumors in SCID mice, suggests that they may serve as valid, useful tools for the elucidation of early events in prostate tumorigenesis. These novel in vitro models may offer unique models for the study of prostate carcinogenesis and also provide the means for testing both chemopreventive and chemotherapeutic agents.
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页码：75 / +
页数：3
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