Immunization with Aβ3-10-KLH vaccine improves cognitive function and ameliorates mitochondrial dysfunction and reduces Alzheimer's disease-like pathology in Tg-APPswe/PSEN1dE9 mice

被引：7

作者：

Zhang, Xiao-Yi ^{[1
]}

Meng, Yuan ^{[2
]}

Yan, Xue-Jing ^{[1
]}

Liu, Shuo ^{[1
]}

Wang, Guo-Qing ^{[1
]}

Cao, Yun-Peng ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Neurol, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Geriatr, Shenyang 110001, Liaoning, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2021年 / 174卷

关键词：

Alzheimer 's disease; Amyloid-beta; A beta 3-10-KLH vaccine; Mitochondrial dysfunction; AMYLOID-BETA; MOUSE MODEL; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; ACTIVE IMMUNIZATION; DYNAMICS; APOPTOSIS; PEPTIDE; PROTEIN; EPITOPE;

D O I：

10.1016/j.brainresbull.2021.05.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease is a common cause of dementia, for which no disease-modifying therapy is yet available. A beta 3-10-KLH, a vaccine for active immunization, has been shown to prevent pathological changes in young transgenic models of AD, but the effects of treatment with it and its effects on mitochondrial dysfunction remain unclear. We immunized 6-month-old Tg-APPswe/PSEN1dE9 mice with A beta 3-10-KLH to analyze whether it is capable of eliminating amyloid-beta after its appearance. The vaccine effectively decreased amyloid-beta deposits, improved cognitive function and ameliorated mitochondrial dysfunction. These results indicate the potential of A beta 3-10-KLH as a vaccine to treat AD.

引用

页码：31 / 40

页数：10

共 23 条

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[23] A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer's disease-like pathology, cognitive decline and synaptic loss in aged 3 x Tg-AD mice
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