Two New N-Oxide Alkaloids from Stemona cochinchinensis

被引：8

作者：

Lin, Ligen ^{[1
,2
]}

Bao, Han ^{[1
]}

Wang, Anqi ^{[1
]}

Tang, Chunping ^{[2
]}

Pham-Huu Dien ^{[3
]}

Ye, Yang ^{[2
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] Hanoi Natl Univ Educ, Fac Chem, Dept Organ Chem, Hanoi 100000, Vietnam

来源：

MOLECULES | 2014年 / 19卷 / 12期

关键词：

Stemona cochinchinensis; Stemonaceae; N-oxide alkaloids; H-1- and C-13-NMR; anti-tussive activity; ROOTS; STEMOCURTISINE; CURTISII;

D O I：

10.3390/molecules191220257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new N-oxide alkaloids with pyrrolo[1,2-alpha]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-alpha]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the H-1- and C-13-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.

引用

页码：20257 / 20265

页数：9

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