The efficient synthesis of alkoxy-esters from hydroxy carboxylic acids using dimsyllithium in dimethylsulfoxide followed by alkylation with an alkyl halide

被引:4
|
作者
Page, PCB [1 ]
Chan, YH [1 ]
Heaney, H [1 ]
McGrath, MJ [1 ]
Moreno, E [1 ]
机构
[1] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England
关键词
hydroxy acids; alkoxyesters; butyllithium; dimethylsulfoxide; dimsyllithium; alkyl halide;
D O I
10.1055/s-2004-834827
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Hydroxy acids are converted directly into the related alkyl ether-alkyl esters in high yields in a single operation by double deprotonation using dimsyllithium in dimethylsulfoxide followed by treatment with an alkyl halide.
引用
收藏
页码:2606 / 2608
页数:3
相关论文
共 45 条