A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines

被引：13

作者：

Ducray, Richard ^{[1
]}

Boutron, Pascal ^{[1
]}

Didelot, Myriam ^{[1
]}

Germain, Herve ^{[1
]}

Lach, Franck ^{[1
]}

Lamorlette, Maryannick ^{[1
]}

Legriffon, Antoine ^{[1
]}

Maudet, Mickael ^{[1
]}

Menard, Morgan ^{[1
]}

Pasquet, Georges ^{[1
]}

Renaud, Fabrice ^{[1
]}

Simpson, Iain ^{[2
]}

Young, Gail L. ^{[2
]}

机构：

[1] AstraZeneca, Res Ctr, ZI Pompelle, F-51689 Reims 2, France

[2] AstraZeneca, Canc Med Chem, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 36期

关键词：

IMIDAZOPYRIDINE ANTICOCCIDIAL AGENTS; DEPENDENT KINASE INHIBITORS; BIOLOGICAL-ACTIVITY; SELECTIVE CLASS; POTENT ACTIVITY; PART II; SAR; HERPESVIRUSES; OPTIMIZATION; DERIVATIVES;

D O I：

10.1016/j.tetlet.2010.07.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step synthesis of 3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridines is presented. The late stage elaboration of the imidazopyridine through a cyclocondensation allows a rapid access to a variety of substitution patterns. The intermediate enol ethers were obtained from inexpensive reagents in a ligand-free Heck coupling. This methodology has been extended to the formation of pyrazolo[1,5-a]pyridines via a formal 1,3-dipolar cycloaddition. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4755 / 4758

页数：4

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