Mice transgenic for Alzheimer disease β-amyloid develop lens cataracts that are rescued by antioxidant treatment

Alzheimer disease is characterized by cerebral A deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Abeta-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These data support an oxidative etiology for AD-associated lens cataracts and their potential to be treated preventatively with antioxidants. (C) 2004 Elsevier Inc. All rights reserved.