Force-Dependent Binding Constants

被引:41
|
作者
Wang, Yinan [1 ]
Yan, Jie [1 ,2 ]
Goult, Benjamin T. [3 ]
机构
[1] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore
[2] Natl Univ Singapore, Mechanobiol Inst, Singapore 117411, Singapore
[3] Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England
基金
英国生物技术与生命科学研究理事会; 新加坡国家研究基金会;
关键词
SURFACE-PLASMON RESONANCE; DNA DOUBLE HELIX; SINGLE-MOLECULE; STRUCTURAL BASIS; VINCULIN-BINDING; MAGNETIC TWEEZERS; OPTICAL TWEEZERS; ACTIN-FILAMENTS; TALIN ROD; MYOSIN-X;
D O I
10.1021/acs.biochem.9b00453
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Life is an emergent property of transient interactions between biomolecules and other organic and inorganic molecules that somehow leads to harmony and order. Measurement and quantitation of these biological interactions are of value to scientists and are major goals of biochemistry, as affinities provide insight into biological processes. In an organism, these interactions occur in the context of forces and the need for a consideration of binding affinities in the context of a changing mechanical landscape necessitates a new way to consider the biochemistry of protein-protein interactions. In the past few decades, the field of mechanobiology has exploded, as both the appreciation of, and the technical advances required to facilitate the study of, how forces impact biological processes have become evident. The aim of this review is to introduce the concept of force dependence of biomolecular interactions and the requirement to be able to measure force-dependent binding constants. The focus of this discussion will be on the mechanotransduction that occurs at the integrin-mediated adhesions with the extracellular matrix and the major mechanosensors talin and vinculin. However, the approaches that the cell uses to sense and respond to forces can be applied to other systems, and this therefore provides a general discussion of the force dependence of biomolecule interactions.
引用
收藏
页码:4696 / 4709
页数:14
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