Immobilization stress increases endogenous monoamine oxidase (MAO) inhibitor in rat liver

被引：1
|
作者：
Obata, Toshio [1 ]
机构：
[1] Ohu Univ, Sch Pharmaceut Sci, Dept Analyt Chem, Fukushima 9638611, Japan
来源：
BIOELECTROCHEMISTRY | 2007年 / 70卷 / 02期
关键词：
monoamine oxidase (MAO); immobilization stress (IMMO); endogenous MAO inhibitor; benzylamine; rat liver;
D O I：
10.1016/j.bioelechem.2006.04.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although the physiological role of endogenous monoamine oxidase (MAO) inhibitor still remains unclear, the present study examined whether or not immobilization stress (IMMO) induce MAO inhibitor. An endogenous inhibitor of MAO was separated by gel filtration from 105,000 g supernate in rat liver cytosol following IMMO. The molecular weight of this inhibitor was estimated to be 500-600 by gel filtration. This inhibitor was proved to be heat-stable resistant to protease treatment. IMMO for 2 h significantly decreased MAO. These results suggest that this inhibitor is induced by IMMO. MAO activity in rat liver might be regulated by the level of this inhibitor. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：308 / 310
页数：3
相关论文
共 50 条
12345