Ultrasound-induced microbubble coalescence

被引:97
|
作者
Postema, M
Marmottant, P
Lancée, CT
Hilgenfeldt, S
De Jong, N
机构
[1] Erasmus MC, Dept Expt Echocardiog, Thoraxctr, NL-3000 DR Rotterdam, Netherlands
[2] Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands
[3] Univ Twente, Fac Sci & Technol, Dept Appl Phys, NL-7500 AE Enschede, Netherlands
来源
ULTRASOUND IN MEDICINE AND BIOLOGY | 2004年 / 30卷 / 10期
关键词
microbubble coalescence; ultrasound contrast agent; film drainage; high-speed photography;
D O I
10.1016/j.ultrasmedbio.2004.08.008
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
We studied the interaction of ultrasound contrast agent bubbles coated with a layer of lipids, driven by 0.5 MHz ultrasound. High-speed photography on the submicrosecond timescale reveals that some bubbles bounce off each other, while others show very fast coalescence during bubble expansion. This fast coalescence cannot be explained by dissipation-limited film drainage rates. We conclude that the lipid shell ruptures upon expansion, exposing clean free bubble interfaces that support plug flow profiles in the film and inertia-limited drainage whose time scales match those of the observed coalescence. (C) 2004 World Federation for Ultrasound in Medicine Biology.
引用
收藏
页码:1337 / 1344
页数:8
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