Enhanced Resolution of Low Molecular Weight Poly(Ethylene Glycol) in Nanopore Analysis

被引：21
|
作者：
Cao, Chan
Ying, Yi-Lun
Gu, Zhen
Long, Yi-Tao [1 ]
机构：
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
来源：
ANALYTICAL CHEMISTRY | 2014年 / 86卷 / 24期
关键词：
ALPHA-HEMOLYSIN NANOPORE; MASS-SPECTROMETRY; POLYETHYLENE-GLYCOL; NUCLEIC-ACIDS; PROTEIN PORE; DNA; TRANSPORT; PEPTIDES; POLYMERS; DYNAMICS;
D O I：
10.1021/ac504233s
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A design with conjugation of DNA hairpin structure to the poly(ethylene glycol) molecule was presented to enhance the temporal resolution of low molecular weight poly(ethylene glycol) in nanopore studies. By the virtue of this design, detection of an individual PEG with molecular weight as low as 140 Da was achieved at the single-molecule level in solution, which provides a novel strategy for characterization of an individual small molecule within a nanopore. Furthermore, we found that the current duration time of poly(ethylene glycol) was scaled with the relative molecular weight, which has a potential application in single-molecule detection.
引用
收藏
页码：11946 / 11950
页数：5
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