Synthesis of cholaphanes by ring closing metathesis

被引：22

作者：

Czajkowska, Dorota ^{[1
]}

Morzycki, Jacek W. ^{[1
]}

机构：

[1] Univ Bialystok, Inst Chem, PL-15443 Bialystok, Poland

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 16期

关键词：

D O I：

10.1016/j.tetlet.2007.02.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of cholaphanes by ring closing metathesis (RCM) of 3 alpha,7 alpha,12 alpha,24-tetraol allyl derivatives, obtained from cholic acid, was attempted. The reactions of tetraol 3,24-diallyl ether or 3,24-diacrylate were not satisfactory. However, diallyl derivatives of disteroidal 3,3'- or 24,24'-ortho-phthalates reacted smoothly affording cyclic dimers in good yields. In all the reactions studied, the E isomers of the macrocycles were obtained in excess. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2851 / 2855

页数：5

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