Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene

被引：3

作者：

Jiang, CL ^{[1
]}

Yu, L ^{[1
]}

Zhao, Y ^{[1
]}

Zhang, M ^{[1
]}

Liu, Q ^{[1
]}

Mao, NH ^{[1
]}

Geng, ZC ^{[1
]}

Zhao, SY ^{[1
]}

机构：

[1] Fudan Univ, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

DNA SEQUENCE | 2000年 / 11卷 / 1-2期

关键词：

CIS1b; splicing variant; cDNA; Northern blot;

D O I：

10.3109/10425170009033983

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

JAK-STAT pathway is essential in relaying cytokine signals and plays a vital role in cellular responses such as proliferation, differentiation and immunity. Some members of a recently found citokine-inducible SH2 protein (CIS, =SOCS or SSI) family have proved to have negative effects on modulating JAK-STAT signaling pathway. In the present study, a novel human cDNA (CIS1b) which proved to be a variant of CIS1 gene was isolated by screen human placenta lambda gt11 cDNA library and 5'-rapid amplification of cDNA ends (RACE). Furthermore, the gene structure of CIS1 was determined by comparing the cDNA sequences of CIS1 and CIS1b to the genomic sequence in human chromosome 3p21.3. The expression patterns of CIS1b as well as CIS1 were analysed by Northern blot.

引用

页码：149 / 154

页数：6

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