This paper studies sequential methods for recovery of sparse signals in high dimensions. When compared with fixed sample size procedures, in the sparse setting, sequential methods can result in a large reduction in the number of samples needed for reliable signal support recovery. Starting with a lower bound, we show any coordinate-wise sequential sampling procedure fails in the high dimensional limit provided the average number of measurements per dimension is less then log(s)/D(P-0 parallel to P-1), where s is the level of sparsity and D(P-0 parallel to P-1) is the Kullback-Leibler divergence between the underlying distributions. A series of sequential probability ratio tests, which require complete knowledge of the underlying distributions is shown to achieve this bound. Motivated by real-world experiments and recent work in adaptive sensing, we introduce a simple procedure termed sequential thresholding, which can be implemented when the underlying testing problem satisfies a monotone likelihood ratio assumption. Sequential thresholding guarantees exact support recovery provided the average number of measurements per dimension grows faster than log(s)/D(P-0 parallel to P-1), achieving the lower bound. For comparison, we show any nonsequential procedure fails provided the number of measurements grows at a rate less than log(n)/D(P-1 parallel to|P-0), where n is the total dimension of the problem.