Recent Advances in the Tandem Difunctionalization of Alkynes: Mechanism-Based Classification

被引：17

作者：

Gao, Biwen ^{[1
]}

Deng, Danfeng ^{[1
]}

Huang, Dayun ^{[1
]}

Sun, Xiangyu ^{[2
]}

机构：

[1] Lishui Univ, Dept Chem, 1 Xueyuan Rd, Lishui City 323000, Zhejiang, Peoples R China

[2] Minist Sci & Technol, Torch High Technol Ind Dev Ctr, 18 Sanlihe Dist, Beijing 100045, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2021年 / 53卷 / 19期

关键词：

alkynes; difunctionalization; mechanism; radicals; tandem reactions; PALLADIUM-CATALYZED DIFUNCTIONALIZATION; SULFUR-MEDIATED DIFUNCTIONALIZATION; DIRECT VICINAL DIFUNCTIONALIZATION; OXIDATIVE IPSO-ANNULATION; TERMINAL ALKYNES; STEREOSELECTIVE DIFUNCTIONALIZATION; ACTIVATED ALKYNES; PROMOTED DIFUNCTIONALIZATION; RADICAL ADDITION/CYCLIZATION; N-ARYLPROPIOLAMIDES;

D O I：

10.1055/a-1486-2158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recent advances on the tandem difunctionalization of alkynes in the last decade (2010-2020) are summarized into five categories based on the type of mechanism: (1) radical addition and coupling for the synthesis of polysubstituted ketones and alkenes, (2) electrophilic addition of alkynes, (3) reactions mediated by haloalkynes or copper acetylides, (4) the preparation of cyclic compounds via radical processes, palladium-catalyzed reactions or conjugate additions, and (5) cyclic compounds as intermediates in ring openings. Herein, radical, electrophilic and nucleophilic reactions are discussed in detail. We hope this review will help to promote future research in this area. 1 Introduction 2 Radical Addition and Coupling 3 Electrophilic Addition 4 Reactions Mediated by Haloalkynes or Copper Acetylides 5 Cyclization 6 Cyclization and Ring Opening 7 Conclusions

引用

页码：3522 / 3534

页数：13

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