Steroids and Brain, a Rising Bio-Medical Domain: a Perspective

被引：4
|
作者：
Baulieu, Etienne-Emile [1 ]
机构：
[1] Univ Paris Saclay, Hop Le Kremlin Bicetre, INSERM, UMR 1195, Val De Marne, France
来源：
FRONTIERS IN ENDOCRINOLOGY | 2018年 / 9卷
关键词：
brain steroids; neurosteroids; Alzheimer's disease; tauopathies; pregnenolone; MAP4343; FKBP52; RU486; MICROTUBULE-ASSOCIATED PROTEIN-2; PREGNENOLONE SULFATE; NERVOUS-SYSTEM; IN-VITRO; DEHYDROEPIANDROSTERONE-SULFATE; PROGESTERONE SYNTHESIS; ALZHEIMERS-DISEASE; MYELIN FORMATION; NEUROSTEROIDS; TAU;
D O I：
10.3389/fendo.2018.00316
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two compounds, "MAP4343," a new neurosteroid very efficient antidepressant, and "FKBP52," a protein component of hetero-oligomeric steroid receptors that we found involved in cerebral function, including in Alzheimer's disease.
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页数：8
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