Neuropsychiatric aspects of treated Wilson's disease

被引：79
|
作者：
Svetel, Marina [1 ]
Potrebic, Aleksandra [2 ]
Pekmezovic, Tanja [3 ]
Tomic, Aleksandra [1 ]
Kresojevic, Nikola [1 ]
Jesic, Rada [4 ]
Dragasevic, Natasa [1 ]
Kostic, Vladimir S. [1 ]
机构：
[1] CCS, Inst Neurol, Belgrade 11000, Serbia
[2] Clin Ctr Serbia, Inst Psychiat, Belgrade 11000, Serbia
[3] Sch Med, Inst Epidemiol, Belgrade, Serbia
[4] Clin Ctr Serbia, Inst Gastroenterol, Belgrade, Serbia
来源：
PARKINSONISM & RELATED DISORDERS | 2009年 / 15卷 / 10期
关键词：
Wilson's disease; Psychiatric symptoms; Neuropsychiatric inventory; PARKINSONS-DISEASE; GENE; DEPRESSION; PSYCHOPATHOLOGY; HUNTINGTONS; SYMPTOMS; DEMENTIA; ATPASE;
D O I：
10.1016/j.parkreldis.2009.01.010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The objective of the current cross-sectional study was to use standardized psychiatric interviews (the Structured Clinical Interview for DSM-IV Axis I Disorders and the Neuropsychiatric Inventory; NPI) in order to better characterize psychiatric symptoms in 50 consecutive, treated and clinically stable patients with Wilson's disease (WD). Nine patients (18%) had one, 7 patients (14%) had two, and 20 (40%) had >= 3 neuropsychiatric symptoms present. The most often enclosed symptoms were anxiety (62%), depression (36%), irritability (26%), as well as disinhibition and apathy (24% each). Twenty two patients (44%) had a score >= 4 on at least one of the NPI items: again, most frequently anxiety (17 patients; 34%), depression (13 patients; 26%) and apathy (9 patients; 18%). Therefore, even among stable, long-term treated patients with WD approximately 70% experienced psychiatric symptoms. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：772 / 775
页数：4
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