Reactive oxygen species generated from skeletal muscles are required for gecko tail regeneration

被引：48

作者：

Zhang, Qing ^{[1
,2
]}

Wang, Yingjie ^{[1
]}

Man, Lili ^{[1
]}

Zhu, Ziwen ^{[1
]}

Bai, Xue ^{[1
]}

Wei, Sumei ^{[1
]}

Liu, Yan ^{[1
]}

Liu, Mei ^{[1
]}

Wang, Xiaochuan ^{[2
]}

Gu, Xiaosong ^{[1
]}

Wang, Yongjun ^{[1
]}

机构：

[1] Nantong Univ, Key Lab Neuroregenerat, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China

[2] Huazhong Univ Sci & Technol, Dept Pathophysiol, Sch Basic Med,Tongji Med Coll, Key Lab,Minist Educ China Neurol Disorders, Wuhan 430030, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

SPINAL-CORD REGENERATION; AUTOPHAGY; ACTIVATION; MEDIATE;

D O I：

10.1038/srep20752

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS functions on spontaneous tail regeneration using gecko model. ROS were mainly produced in the skeletal muscle after tail amputation, showing a temporal increase as the regeneration proceeded. Inhibition of the ROS production influenced the formation of autophagy in the skeletal muscles, and as a consequence, the length of the regenerating tail. Transcriptome analysis has shown that NADPH oxidase (NOX2) and the subunits (p40(phox) and p47(phox)) are involved in the ROS production. ROS promoted the formation of autophagy through regulation of both ULK and MAPK activities. Our results suggest that ROS produced by skeletal muscles are required for the successful gecko tail regeneration.

引用

页数：11

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