Outcomes and toxicities of re-irradiation for prostate cancer: A systematic review on behalf of the Re-Irradiation Working Group of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)

被引:22
|
作者
Munoz, Fernando [1 ]
Fiorica, Francesco [2 ]
Caravatta, Luciana [3 ]
Rosa, Consuelo [3 ]
Ferella, Letizia [1 ]
Boldrini, Luca [4 ]
Fionda, Bruno [4 ]
Alitto, Anna Rita [4 ]
Nardangeli, Alessia [4 ]
Dionisi, Francesco [5 ]
Arcangeli, Stefano [6 ,7 ]
Di Marzo, Alessandro [8 ]
Pontoriero, Antonio [9 ]
Donato, Vittorio [10 ]
Massaccesi, Mariangela [4 ]
机构
[1] Parini Hosp, Radiotherapy Unit, Viale Ginevra 3, I-11100 Aosta, Italy
[2] State Hosp Mater Salutis AULSS 9, Dept Radiat Oncol & Nucl Med, Via Carlo Gianella 1, I-37045 Legnago, VR, Italy
[3] Univ G dAnnunzio, SS Annunziata Hosp, Radiat Oncol Unit, Via Vestini, I-66100 Chieti, Italy
[4] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Dept Radiol Radiotherapy & Hematol Sci, Via Pineta Sacchetti 217, I-00168 Rome, Italy
[5] APSS, Proton Therapy Unit, Dept Oncol, Via Alcide Degasperi 79, I-38123 Trento, Italy
[6] Policlin S Gerardo, Dept Radiat Oncol, Via Sansovino 4, I-20133 Milan, Italy
[7] Univ Milano Bicocca, Via Sansovino 4, I-20133 Milan, Italy
[8] S Maria Hosp, Radiotherapy Oncol Ctr, Viale Tristano Joannuccio, I-05100 Terni, Italy
[9] Univ Hosp G Martino, Dept Image Diagnost, Operat Unit Radiat Oncol, Messina, Italy
[10] Azienda Osped San Camillo Forlanini, Radiat Oncol, Circonvallaz Gianicolense 87, I-00152 Rome, Italy
关键词
Cumulative dose; Outcomes; Prostate cancer; Re-irradiation; Toxicity; DOSE-RATE BRACHYTHERAPY; BEAM RADIATION-THERAPY; SALVAGE BRACHYTHERAPY; RECURRENCE; FAILURE;
D O I
10.1016/j.ctrv.2021.102176
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: The best therapeutic approach for local relapses of previously irradiated prostate cancer (PC) is still not defined. Re-irradiation (Re-I) could offer a chance of cure for highly selected patients, although high quality evidences are lacking. The aim of our study is to provide a literature review on efficacy and safety of Re-I. Methods: Only studies where Re-I field overlaps with previous radiotherapy were considered. To determine 2 and 4 years overall mortality (OM), 2 and 4 years biochemical failure (BF) and pooled acute and late G 0.001). The pooled result of G 0.001). One hundred and three G 3 late adverse events were reported, with a pooled result of G > 3 late toxicity of 8.7% (95%CI: 5.8?13%, P < 0.001). Conclusions: Re-I of local failures from PC showed promising OM and biochemical control rates with a safe toxicity profile.
引用
收藏
页数:10
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