Synthesis and membrane permeability of PNA-peptide conjugates

被引：91
|
作者：
Simmons, CG
Pitts, AE
Mayfield, LD
Shay, JW
Corey, DR
机构：
[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dept Pharmacol, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Dept Cell Biol & Neurosci, Dallas, TX 75235 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0960-894X(97)10136-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chimeric molecules consisting of peptide nucleic acid oligomers (PNAs) and peptides derived from the third helix of the homeodomain of Antennapedia are taken up by mammalian cells in culture. Uptake is independent of orientation and occurs with high efficiency, suggesting that peptide conjugates are a promising strategy for intracellular PNA delivery. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：3001 / 3006
页数：6
相关论文
共 50 条
  • [21] miR-122 targeting with LNA/2′-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates
    Fabani, Martin M.
    Gait, Michael J.
    RNA, 2008, 14 (02) : 336 - 346
  • [22] Detection of oligonucleotides by PNA-peptide conjugates recognizing the biarsenical fluorescein complex FlAsH-EDT2
    Piras, Linda
    Avitabile, Concetta
    D'Andrea, Luca Domenico
    Saviano, Michele
    Romanelli, Alessandra
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 493 (01) : 126 - 131
  • [23] Automated Flow Synthesis of Peptide-PNA Conjugates
    Li, Chengxi
    Callahan, Alex J.
    Phadke, Kruttika S.
    Bellaire, Bryan
    Farquhar, Charlotte E.
    Zhang, Genwei
    Schissel, Carly K.
    Mijalis, Alexander J.
    Hartrampf, Nina
    Loas, Andrei
    Verhoeven, David E.
    Pentelute, Bradley L.
    ACS CENTRAL SCIENCE, 2022, 8 (02) : 205 - 213
  • [24] Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA
    Yavari, Niloofar
    Goltermann, Lise
    Nielsen, Peter E.
    ACS CHEMICAL BIOLOGY, 2021, 16 (03) : 471 - 479
  • [25] Self-assembled proteomimetic (SAP) with antibody- like binding from short PNA-peptide conjugates
    Brennecke, Benjamin
    Civili, Beatrice
    Sabale, Pramod M.
    Barluenga, Sofia
    Meyer, Benjamin
    Winssinger, Nicolas
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 122 (07)
  • [26] PNA-peptide conjugates for regulation of DNA and RNA G-quadruplex structures depending on a particular protease concentration
    Usui, K.
    Kobayashi, K.
    Sugimoto, N.
    JOURNAL OF PEPTIDE SCIENCE, 2010, 16 : 197 - 197
  • [27] Sequence Selective Recognition of Double-Stranded RNA at Physiologically Relevant Conditions Using PNA-Peptide Conjugates
    Muse, Oluwatoyosi
    Zengeya, Thomas
    Mwaura, Juddy
    Hnedzko, Dziyana
    McGee, Dennis W.
    Grewer, Christof T.
    Rozners, Eriks
    ACS CHEMICAL BIOLOGY, 2013, 8 (08) : 1683 - 1686
  • [28] Extending recognition by peptide nucleic acids (PNAs): Binding to duplex DNA and inhibition of transcription by tail-clamp PNA-Peptide conjugates
    Kaihatsu, K
    Shah, RH
    Zhao, X
    Corey, DR
    BIOCHEMISTRY, 2003, 42 (47) : 13996 - 14003
  • [29] Transcription activation by a PNA-peptide chimera in a mammalian cell extract
    Liu, B
    Han, Y
    Ferdous, A
    Corey, DR
    Kodadek, T
    CHEMISTRY & BIOLOGY, 2003, 10 (10): : 909 - 916
  • [30] Strand invasion by mixed base PNAs and a PNA-peptide chimera
    Zhang, X
    Ishihara, T
    Corey, DR
    NUCLEIC ACIDS RESEARCH, 2000, 28 (17) : 3332 - 3338
12345