Pd-Catalyzed Dehydrogenative Aryl-Aryl Bond Formation via Double C(sp2)-H Bond Activation:, Efficient Synthesis of [3,4]-Fused Oxindoles

被引：60
|
作者：
Bunescu, Ala [1 ]
Piou, Tiffany [1 ]
Wang, Qian [1 ]
Zhu, Jieping [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Lab Synth & Nat Prod, Inst Chem Sci & Engn, EPFL SB ISIC LSPN, CH-1015 Lausanne, Switzerland
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 02期
基金：
瑞士国家科学基金会;
关键词：
C-H ACTIVATION; INTRAMOLECULAR HECK REACTION; PALLADIUM MIGRATION; DOMINO REACTION; CYCLIZATION; SPIROOXINDOLES; CONSTRUCTION; CASCADE; REARRANGEMENT; POLYFLUORENES;
D O I：
10.1021/ol503442n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp(2))H functionalization steps.
引用
收藏
页码：334 / 337
页数：4
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