Synthesis of [C-11]methyl ketones via [C-11]methylation of dithiane intermediates

被引：0

作者：

Elsinga, PH

Fluks, E

Franssen, EJF

Visser, GM

Vaalburg, W

机构：

[1] PET-Center, Groningen University Hospital, 9700 RB Groningen

来源：

APPLIED RADIATION AND ISOTOPES | 1996年 / 47卷 / 01期

关键词：

D O I：

10.1016/0969-8043(95)00248-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A versatile synthetic route to obtain [C-11]methyl ketones from aldehydes is described. Test reactions with [C-11]CH3I on the model compounds 2-methyl- and 2-cyclohexyl- 1,3-dithiane followed by oxidation with N-bromosuccinimide gave almost quantitative radiochemical yields. Reaction of [C-11]CH3I with 2-phenylethyl-1,3-dithiane yielded the corresponding [C-11]methyl ketone in 80% radiochemical yield together with an unidentified side-product on oxidation with N-bromosuccinimide.

引用

页码：57 / 59

页数：3

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