Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case

被引：11
|
作者：
Takeguchi-Kikuchi, Shiori [1 ]
Hayasaka, Taiki [2 ]
Katayama, Takayuki [1 ]
Kano, Kohei [1 ]
Takahashi, Kae [1 ]
Saito, Tsukasa [1 ]
Sawada, Jun [1 ]
Minoshima, Akiho [2 ]
Sakamoto, Naka [2 ]
Akasaka, Kazumi [2 ]
Miyokawa, Naoyuki [3 ]
Nishino, Ichizo [4 ]
Ishibashi-Ueda, Hatsue [5 ]
Hasebe, Naoyuki [1 ,2 ]
机构：
[1] Asahikawa Med Univ, Dept Internal Med 1, Div Neurol, Asahikawa, Hokkaido, Japan
[2] Asahikawa Med Univ, Dept Internal Med 1, Div Cardiol, Asahikawa, Hokkaido, Japan
[3] Asahikawa Med Univ, Dept Clin Pathol, Asahikawa, Hokkaido, Japan
[4] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Neuromuscular Res, Kodaira, Tokyo, Japan
[5] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Suita, Osaka, Japan
来源：
INTERNAL MEDICINE | 2019年 / 58卷 / 21期
关键词：
anti-signal recognition particle (SRP) antibody; necrotizing myopathy; cardiomyopathy; myocardial biopsy; positron-emission tomography (PET); AUTOANTIBODIES; ASSOCIATION;
D O I：
10.2169/internalmedicine.2564-18
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped. but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. F-18-fluorodeoxyglucose-positron emission tomography showed an abnormal uptake, and magnetic resonance imaging showed abnormal gadolinium enhancement in the left ventricular wall. An endomyocardial biopsy revealed inflammatory cardiomyopathy. Steroid, tacrolimus, and intravenous immunoglobulins were effective against the symptoms. This is the first case of biopsy-proven secondary cardiomyopathy due to anti-SRP-positive NM.
引用
收藏
页码：3189 / 3194
页数：6
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  • [1] Anti-signal recognition particle antibody-positive immune-mediated necrotizing myopathy treated with ofatumumab
    Wen, Chunbei
    Yang, Jie
    Wei, Dongsheng
    Xu, Changyou
    Yu, Ping
    Luo, Lijun
    [J]. RHEUMATOLOGY, 2024, 63 (02)
  • [2] Hip abductor weakness in anti-signal recognition particle antibody-positive myopathy
    Yamada, Takayuki
    Kobayashi, Zen
    Inoue, Keisuke
    Tomimitsu, Hiroyuki
    [J]. NEUROLOGY AND CLINICAL NEUROSCIENCE, 2022, 10 (02): : 102 - 104
  • [3] Thrombotic microangiopathy in a patient with anti-signal recognition particle antibody-positive immune-mediated necrotizing myopathy
    Sakai, Kenji
    Takahashi, Megumi
    Ito, Yumi
    Yamada, Shota
    Ito, Toru
    Higuchi, Yo
    Kameda, Shigemi
    [J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2024, 27 (01)
  • [4] Tacrolimus in combination with methotrexate and corticosteroid for the treatment of child-onset anti-signal recognition particle antibody-positive necrotizing myopathy
    Kobayashi, I.
    Tozawa, Y.
    Ueki, M.
    Takezaki, S.
    Watanabe, S.
    Iwafuchi, H.
    Yamada, M.
    Kuwana, M.
    Ariga, T.
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2017, 46 (05) : 409 - 410
  • [5] Influenza A (H3N2) infection followed by anti-signal recognition particle antibody-positive necrotizing myopathy: A case report
    Iriki, Jun
    Yamamoto, Kazuko
    Senju, Hiroaki
    Nagaoka, Atsushi
    Yoshida, Masataka
    Iwasaki, Keisuke
    Ashizawa, Nobuyuki
    Hirayama, Tatsuro
    Tashiro, Masato
    Takazono, Takahiro
    Imamura, Yoshifumi
    Miyazaki, Taiga
    Izumikawa, Koichi
    Yanagihara, Katsunori
    Tsujino, Akira
    Fukuoka, Junya
    Uetani, Masataka
    Satoh, Minoru
    Mukae, Hiroshi
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2021, 103 : 33 - 36
  • [6] Autoimmune necrotizing myopathy with anti-signal recognition particle antibodies in the first year of life
    Camacho, A.
    Ghandour, D.
    De Inocencio, J.
    Hernandez Lain, A.
    Toldos, O.
    Vila, S.
    Nunez, N.
    Simon, R.
    [J]. NEUROMUSCULAR DISORDERS, 2021, 31 : S50 - S50
  • [7] Pathological Changes of Necrotizing Autoimmune Myopathy Associated with Anti-Signal Recognition Particle Antibody
    Shimizu, Jun
    Maeda, Meiko
    Date, Hidetoshi
    Tsuji, Shoji
    [J]. NEUROLOGY, 2013, 80
  • [8] Clinical features and treatment outcome of four patients with anti-signal recognition particle antibody positive necrotizing myopathy
    Nomura, S.
    Ueno, A.
    Miyazaki, D.
    Kishida, D.
    Hineno, A.
    Shimojima, Y.
    Sekijima, Y.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 381 : 657 - 658
  • [9] Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody
    Kusumoto, Tatsuya
    Okamori, Satoshi
    Masuzawa, Keita
    Asakura, Takanori
    Nishina, Naoshi
    Chubachi, Shotaro
    Naoki, Katsuhiko
    Fukunaga, Koichi
    Betsuyaku, Tomoko
    [J]. INTERNAL MEDICINE, 2018, 57 (14) : 2045 - 2049
  • [10] Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy: A Case Report
    Belkhribchia, Mohamed Reda
    Lobrinus, Johannes Alexander
    Semlil, Lamyaa
    Chauveau, Nicolas
    Ajrinija, Abdelaziz
    Egervari, Kristof
    Ennhaili, Zine Elabidine
    [J]. JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS, 2024, 12
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