Development of Necrotizing Myopathy Following Interstitial Lung Disease with Anti-signal Recognition Particle Antibody

被引：17

作者：

Kusumoto, Tatsuya ^{[1
]}

Okamori, Satoshi ^{[1
]}

Masuzawa, Keita ^{[1
]}

Asakura, Takanori ^{[1
]}

Nishina, Naoshi ^{[2
]}

Chubachi, Shotaro ^{[1
]}

Naoki, Katsuhiko ^{[1
]}

Fukunaga, Koichi ^{[1
]}

Betsuyaku, Tomoko ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Med, Div Pulm Med, Tokyo, Japan

[2] Keio Univ, Sch Med, Dept Med, Div Rheumatol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 14期

基金：

日本学术振兴会;

关键词：

anti-signal recognition particle antibody; anti-SRP antibody; ILD; interstitial lung disease; necrotizing myopathy; INFLAMMATORY MYOPATHY; HUMAN AUTOANTIBODIES; JAPANESE PATIENTS; PNEUMONIA; POLYMYOSITIS; MYOSITIS; PATIENT;

D O I：

10.2169/internalmedicine.0303-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 72-year-old man was admitted due to dyspnea on exertion with interstitial shadows and elevated serum creatinine kinase (CK). Despite a close examination, which included magnetic resonance imaging (MRI), we could not diagnose myopathy. Prednisolone was administered and gradually tapered. One year later, anti-signal recognition particle (SRP) antibody was confirmed and he was re-admitted for hypoxemia with elevated CK. MRI revealed muscle edema and a histopathological examination of a muscle biopsy specimen showed necrotizing myopathy. Prednisolone, cyclosporine, and intravenous immunoglobulin were administered. Physicians should carefully monitor muscle symptoms and serum CK levels in cases of interstitial lung disease with anti-SRP antibodies.

引用

页码：2045 / 2049

页数：5

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