Supramolecular assemblies of novel aminonucleoside phospholipids and their bonding to nucleic acids

被引：15

作者：

Pan, Delin ^{[1
]}

Sun, Jing ^{[1
]}

Jin, Hongwei ^{[1
]}

Li, Yating ^{[1
]}

Li, Liyu ^{[1
]}

Wu, Yun ^{[1
]}

Zhang, Lihe ^{[1
]}

Yang, Zhenjun ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 03期

关键词：

MOLECULAR RECOGNITION; DNA CONDENSATION; SIRNA DELIVERY; GENE DELIVERY; PEPTIDE; OLIGONUCLEOTIDE; AMPHIPHILES; NUCLEOSIDE; CHEMISTRY; CONSTRUCTION;

D O I：

10.1039/c4cc07538b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of aminonucleoside phospholipids has been developed. These molecules could spontaneously assemble into supramolecular structures including multilamellar organization, hydrogels, superhelical strands, and vesicles. Their ability to bind to DNA by hydrogen bonding and pi-pi stacking interactions was investigated by many means.

引用

页码：469 / 472

页数：4

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