Treatment of Multiple Myeloma and the Role of Melphalan in the Era of Modern Therapies-Current Research and Clinical Approaches

被引：38
|
作者：
Poczta, Anastazja [1 ]
Rogalska, Aneta [1 ]
Marczak, Agnieszka [1 ]
机构：
[1] Univ Lodz, Inst Biophys, Fac Biol & Environm Protect, Dept Med Biophys, Pomorska 141-143, PL-90236 Lodz, Poland
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 09期
关键词：
autologous stem cell transplantation; clinical study; combination chemotherapy; high dose melphalan therapy; in vitro and in vivo studies; multiple myeloma; STEM-CELL TRANSPLANTATION; HIGH-DOSE MELPHALAN; IN-VITRO; AUTOLOGOUS TRANSPLANTATION; MAINTENANCE THERAPY; DRUG-RESISTANCE; 140 MG/M(2); POPULATION PHARMACOKINETICS; INTRAVENOUS MELPHALAN; PLUS LENALIDOMIDE;
D O I：
10.3390/jcm10091841
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiple myeloma (MM) accounts for 10% of all hematological malignancies, and it is the second most common hematological neoplasm for which chemotherapy is an important pharmacological treatment. High dose melphalan followed by autologous stem cell transplantation remains the standard of treatment for transplant-eligible patients with MM. In this review, we describe aspects of the pharmacokinetics and pharmacodynamics of melphalan therapy and related compounds. In addition, we describe the use of melphalan in innovative therapies for the treatment of MM, including the development of drug carriers to reduce systemic toxicity, combination therapy to improve the effectiveness of cancer therapy, and the chemical modification of the melphalan molecule to improve antitumor activity.
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页数：23
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