Left behind: The potential impact of CFTR modulators on racial and ethnic disparities in cystic fibrosis

被引：33

作者：

McGarry, Meghan E. ^{[1
]}

Gibb, Elizabeth R. ^{[1
]}

Oates, Gabriela R. ^{[2
]}

Schechter, Michael S. ^{[3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, Div Pulm Med, San Francisco, CA 94110 USA

[2] Univ Alabama Birmingham, Dept Pediat, Div Pulm & Sleep Med, Birmingham, AL USA

[3] Virginia Commonwealth Univ, Dept Pediat, Div Pulm & Sleep Med, Richmond, VA USA

[4] Childrens Hosp Richmond VCU, Richmond, VA USA

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2022年 / 42卷

关键词：

Cystic fibrosis; CFTR modulators; Race; Ethnicity; CIGARETTE-SMOKE; TEZACAFTOR-IVACAFTOR; SOCIOECONOMIC-STATUS; DOUBLE-BLIND; HISPANIC PATIENTS; EPITHELIAL-CELLS; PHE508DEL CFTR; PARALLEL-GROUP; RISK-FACTORS; US FOOD;

D O I：

10.1016/j.prrv.2021.12.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The advent of CFTR modulators, a genomic specific medication, revolutionized the treatment of CF for many patients. However, given that these therapeutics were only developed for specific CFTR mutations, not all people with CF have access to such disease-modifying drugs. Racial and ethnic minority groups are less likely to have CFTR mutations that are approved for CFTR modulators. This exclusion has the potential to widen existing health disparities.(c) 2021 Elsevier Ltd. All rights reserved.

引用

页码：35 / 42

页数：8

共 50 条

[1] Nutritional impact of CFTR modulators in children with cystic fibrosis
Gaschignard, Margaux
Beaufils, Fabien
Lussac-Sorton, Florian
Gallet, Pauline
Clouzeau, Haude
Menard, Joris
Costanzo, Aurelie
Nouard, Lucie
Delhaes, Laurence
Tetard, Candice
Lamireau, Thierry
Fayon, Michael
Bui, Stephanie
Enaud, Raphael
FRONTIERS IN PEDIATRICS, 2023, 11
[2] CFTR MODULATORS FOR CYSTIC FIBROSIS
Passi, Gouri Rao
INDIAN PEDIATRICS, 2017, 54 (12) : 1060 - 1060
[3] Impact of CFTR modulators on exercise capacity in adolescents with cystic fibrosis
Ahmed, Molla Imaduddin
Dayman, Naomi
Blyth, Natalie
Madge, Joe
Gaillard, Erol
ERJ OPEN RESEARCH, 2024, 10 (01)
[4] PULMONOLOGY CFTR modulators for cystic fibrosis
Bertoncini, Erica
Colomb-Lippa, Dawn
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS, 2013, 26 (02): : 59 - 60
[5] Treatment of Cystic Fibrosis with CFTR Modulators
Tuemmler, B.
PNEUMOLOGIE, 2016, 70 (05): : 301 - 313
[6] CFTR Modulators for the Treatment of Cystic Fibrosis
Hadida, Sabine
Van Goor, Fredrick
Grootenhuis, Peter D. J.
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45, 2010, 45 : 157 - 173
[7] Perception and participation in sport and exercise in cystic fibrosis: The impact of CFTR modulators
Berthold, Akos
Barr, Eileen
Kasi, Ajay
Lichten, Lauren
Hunt, William R.
RESPIRATORY MEDICINE, 2024, 235
[8] CFTR Modulators: Impact on Fertility, Pregnancy, and Lactation in Women with Cystic Fibrosis
Taylor-Cousar, Jennifer L.
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (09) : 1 - 11
[9] Cystic fibrosis transmembrane regulator (CFTR) modulators
不详
EXPERT OPINION ON THERAPEUTIC PATENTS, 2005, 15 (04) : 471 - 474
[10] Discovery of CFTR modulators for the treatment of cystic fibrosis
Hadida-Ruah, Sara
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251

← 1 2 3 4 5 →