The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the βPIX guanine nucleotide exchange factor for Rac1 and Cdc42
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作者:
Park, E
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Park, E
Na, M
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Na, M
Choi, JH
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Choi, JH
Kim, S
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Kim, S
Lee, JR
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Lee, JR
Yoon, JY
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Yoon, JY
Park, D
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Park, D
Sheng, M
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机构:Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Sheng, M
Kim, E
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Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South KoreaKorea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
Kim, E
[1
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机构:
[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
[2] Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea
[3] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[4] MIT, RIKEN MIT Neurosci Res Ctr, Picower Ctr Learning & Memory, Cambridge, MA 02139 USA
The Shank/ProSAP family of multidomain proteins is known to play an important role in organizing synaptic multiprotein complexes. Here we report a novel interaction between Shank and betaPIX, a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases. This interaction is mediated by the PDZ domain of Shank and the C-terminal leucine zipper domain and the PDZ domain-binding motif at the extreme C terminus of betaPIX. Shank colocalizes with betaPIX at excitatory synaptic sites in cultured neurons. In brain, Shank forms a complex with betaPIX and betaPIX-associated signaling molecules including p21-associated kinase (PAK), an effector kinase of Rac1/Cdc42. Importantly, overexpression of Shank in cultured neurons promotes synaptic accumulation of betaPIX and PAK. Considering the involvement of Rac1 and PAK in spine dynamics, these results suggest that Shank recruits betaPIX and PAK to spines for the regulation of postsynaptic structure.
机构:
Shaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Wang, Xifang
Zhang, Xiaomin
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Xian Int Med Ctr Hosp, Dept Orthopaed, Xian 710100, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Zhang, Xiaomin
Sun, Jingying
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Shaanxi Prov Peoples Hosp, Shaanxi Prov Key Lab Infect & Immunol Dis, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Sun, Jingying
Sun, Yang
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Shaanxi Prov Peoples Hosp, Data Ctr, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Sun, Yang
Zhang, Yuan
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Shaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Zhang, Yuan
He, Li
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Shaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
He, Li
Wang, Ping
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Shaanxi Prov Peoples Hosp, Dept Pathol, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Wang, Ping
Li, Feng
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Capital Med Univ, Dept Pathol, Beijing 100020, Peoples R China
Capital Med Univ, Beijing Chaoyang Hosp, Med Res Ctr, Beijing 100020, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Li, Feng
Sun, Chao
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Shaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China
Shaanxi Prov Peoples Hosp, Dept Med Oncol, 256 Youyi West Rd, Xian 710068, Peoples R ChinaShaanxi Prov Peoples Hosp, Dept Med Oncol, Xian 710068, Peoples R China