Synthesis and Antimicrobial Evaluation of Novel Dibenzo-18-Crown-6-Ether Functionalized Pyrimidines

被引：2
|
作者：
Jagadale, S. D. [1 ]
Sawant, A. D. [2 ]
Deshmukh, M. B. [3 ]
机构：
[1] Shivaji Univ, Sch Nanosci & Biotechnol, Kolhapur 416004, Maharashtra, India
[2] Sanjay Ghodawat Inst, Dept Chem, Kolhapur 416118, Maharashtra, India
[3] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 04期
关键词：
STEP SYNTHESIS; GUANIDINE;
D O I：
10.1002/jhet.2818
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical, two-step synthesis of crown ether functionalized pyrimidines has been developed. The reaction conditions have been optimized, and the protocol is generalized for series of substrates. These newly synthesized compounds exhibited antimicrobial activity against bacterial strains Staphylcoccus aureus (Gram-positive) and Escherichia coli (Gram-negative). These compounds were also found to be potent antifungal agents Aspergillus niger and Candida albicans strains, respectively.
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页码：2307 / 2312
页数：6
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