The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease

被引：78

作者：

Wu, Hao ^{[1
]}

Dunnett, Sophie ^{[1
]}

Ho, Yuen-Shan ^{[2
]}

Chang, Raymond Chuen-Chung ^{[1
,3
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Sch Biomed Sci, Lab Neurodegenerat Dis,Pokfulam, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hung Hom, Hong Kong, Peoples R China

[3] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Pokfulam, Hong Kong, Peoples R China

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2019年 / 54卷

关键词：

Sleep; Circadian rhythm; Alzheimer's disease; Glymphatic; Dural lymphatics; Orexin; Oxidative stress; Melatonin; Stress granules; MILD COGNITIVE IMPAIRMENT; BRAIN INTERSTITIAL FLUID; TIME-DEPENDENT CHANGES; CENTRAL-NERVOUS-SYSTEM; SELF-REPORTED SLEEP; OREXIN-A LEVELS; CHRONIC JET-LAG; REV-ERB-ALPHA; OXIDATIVE STRESS; AMYLOID-BETA;

D O I：

10.1016/j.yfrne.2019.100764

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., beta-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly; this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.

引用

页数：14

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