Distinct Roles for IL-2 and IL-15 in the Differentiation and Survival of CD8+ Effector and Memory T Cells

被引:98
|
作者
Mitchell, Diana M. [1 ]
Ravkov, Eugene V. [1 ]
Williams, Matthew A. [1 ]
机构
[1] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA
来源
JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 12期
基金
美国国家卫生研究院;
关键词
CHRONIC VIRAL-INFECTION; RECOMBINANT LISTERIA-MONOCYTOGENES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; CUTTING EDGE; TRANSCRIPTION FACTOR; METASTATIC MELANOMA; SECONDARY EXPANSION; CD8-T-CELL MEMORY; IMMUNE-RESPONSES; CD4-T-CELL HELP;
D O I
10.4049/jimmunol.0904089
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IL-2 provides a memory differentiation signal to CD8(+) T cells during the primary response that impacts the ability of the subsequent memory pool to mount a successful recall response. In this study, we find that although primary effector CTL development is modestly decreased in the absence of IL-2, the persistence of short-term and long-term effector memory CD8(+) T cells on pathogen clearance is greatly diminished. Furthermore, secondary challenge of CD8(+) memory T cells lacking the highavidity IL-2R results in a failure to repopulate the effector pool. The role of IL-2 in promoting effector differentiation is not shared with the highly related cytokine, IL-15. Although IL-15 supports the survival of effector CD8(+) T cells after pathogen clearance, its absence does not impair either primary or secondary effector CTL differentiation, nor does it impact the differentiation of long-term effector memory CD8(+) T cells. These findings indicate a unique role for IL-2, but not IL-15, in promoting the differentiation not only of primary effector CD8(+) T cells, but also of CD8(+) memory T cells capable of secondary effector differentiation. The Journal of Immunology, 2010, 184: 6719-6730.
引用
收藏
页码:6719 / 6730
页数:12
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